Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01KIU
|
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| Former ID |
DIB000285
|
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| Drug Name |
PRE-084
|
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| Drug Type |
Small molecular drug
|
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| Company |
INSERM
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C19H27NO3
|
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| InChI |
InChI=1S/C19H27NO3/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17/h1,3-4,7-8H,2,5-6,9-16H2
|
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| InChIKey |
RQHKZUBCUZVZEF-UHFFFAOYSA-N
|
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| CAS Number |
CAS 138847-85-5
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
6443277, 10241571, 11111621, 11113583, 14850372, 26751787, 29305975, 47276721, 50104478, 53790762, 57341759, 75261716, 85788102, 90341330, 103272556, 103946436, 104363572, 124750104, 124881085, 124881086, 124881087, 126435879, 129166397, 135083631, 137146243, 141232620, 162223394, 178103290, 179235769, 231378769
|
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| Target and Pathway | |||||
| Target(s) | Sigma(1)-type opioid receptor | Target Info | Modulator | [526642], [530642], [532713] | |
| References | |||||
| Ref 532130 | Self-administration of cocaine induces dopamine-independent self-administration of sigma agonists. Neuropsychopharmacology. 2013 Mar;38(4):605-15. | ||||
| Ref 541783 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6678). | ||||
| Ref 526642 | Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6. | ||||
| Ref 530642 | Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice. Pharmacol Rep. 2009 Nov-Dec;61(6):1179-83. | ||||
| Ref 532713 | Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. | ||||
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