Drug Information

Drug General Information
Drug ID
D01KQA
Former ID
DAP000380
Drug Name
Nalbuphine
Synonyms
Intapan; Nalbufina; Nalbuphinum; Intapan (TN); Nalbuphine (INN); Nubain (TN); (5alpha,6alpha)-17-(cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol; 17-cyclobutylmethyl-4,5alpha-epoxymorphinan-3,6alpha,14-triol
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Approved [538227], [539027]
Therapeutic Class
Analgesics
Company
Endo Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C21H27NO4
InChI
InChI=1S/C21H27NO4/c23-14-5-4-13-10-16-21(25)7-6-15(24)19-20(21,17(13)18(14)26-19)8-9-22(16)11-12-2-1-3-12/h4-5,12,15-16,19,23-25H,1-3,6-11H2/t15-,16+,19-,20-,21+/m0/s1
InChIKey
NETZHAKZCGBWSS-CEDHKZHLSA-N
CAS Number
CAS 20594-83-6
PubChem Compound ID
5311304
PubChem Substance ID
9460, 7980064, 11056425, 11466146, 11467266, 11485811, 14828107, 14828108, 39341002, 46507383, 47216707, 47291070, 48110387, 48259160, 48416304, 49698355, 50968490, 56464121, 57359427, 85787879, 92308840, 93166218, 96024934, 103234668, 104000882, 124893623, 126666056, 127291528, 127291529, 127291530, 127291531, 127291532, 127291533, 128691869, 134223042, 134337690, 134993850, 135650680, 137005112, 139813937, 144205561, 164230822, 164763215, 175267073, 176484045, 179116802, 223663773, 223893850, 226395880, 252354412
ChEBI ID
ChEBI:7454
SuperDrug ATC ID
N02AF02
SuperDrug CAS ID
cas=020594836
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Modulator [556264]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 538227FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 070692.
Ref 539027(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1663).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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