Drug Information

Drug General Information
Drug ID
D01LWZ
Former ID
DNC008111
Drug Name
2-chloro-N6-cyclopentyladenosine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540509]
Structure
Download
2D MOL
Formula
C15H20ClN5O4
InChI
InChI=1S/C15H20ClN5O4/c16-15-19-12(18-7-3-1-2-4-7)9-13(20-15)21(6-17-9)14-11(24)10(23)8(5-22)25-14/h6-8,10-11,14,22-24H,1-5H2,(H,18,19,20)/t8-,10-,11-,14-/m1/s1
InChIKey
XSMYYYQVWPZWIZ-IDTAVKCVSA-N
PubChem Compound ID
123807
PubChem Substance ID
7978870, 10240867, 14926452, 15077639, 24892583, 26752235, 29303998, 47583681, 47657043, 47880040, 47954406, 48253885, 48253886, 49865076, 51243784, 57340594, 81044344, 85177284, 91703424, 103212393, 103985068, 104419371, 126660210, 129734712, 134345316, 135079214, 135651141, 135651453, 135697905, 141602533, 162093815, 162130926, 163410111, 163848507, 164823195, 184566468, 202562977, 223556784, 223669070, 223987835, 226492042, 241066841, 252156050, 252215107, 252361355, 252485774
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Inhibitor [529098]
Adenosine A2b receptor Target Info Inhibitor [529098]
Adenosine A2a receptor Target Info Inhibitor [529098]
Adenosine A3 receptor Target Info Inhibitor [529098]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addictionhsa04015:Rap1 signaling pathway
Calcium signaling pathway
Vascular smooth muscle contraction
Alcoholismhsa04015:Rap1 signaling pathway
Parkinson's disease
Alcoholism
NetPath Pathway TCR Signaling Pathway
RANKL Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway Interaction Database C-MYB transcription factor networkhif2pathway:HIF-2-alpha transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome Adenosine P1 receptors
G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolismR-HSA-187024:NGF-independant TRKA activation
Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
Monoamine Transport
NGF signalling via TRKA from the plasma membrane
GPCR downstream signaling
GPCRs, OtherWP80:Nucleotide GPCRs
GPCRs, Other
References
Ref 540509(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 374).
Ref 529098Bioorg Med Chem. 2008 Jan 1;16(1):336-53. Epub 2007 Sep 22.5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivityfor A1 receptor from different species.

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