Drug General Information
Drug ID	D01LXG
Former ID	DIB006505
Drug Name	KC-11425
Indication	Asthma [ICD10:J45]		Terminated	[545947]
Company	Solvay Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	n12c(c(c3c1c(cc(c3)CC(C)C)CCC2)CCN1CCN(c2nccc(c2)C)CC1)<br />C.Cl.Cl
CAS Number	CAS 148468-63-7
Target and Pathway
Target(s)	Platelet-activating factor receptor	Target Info	Antagonist	[551926]
	Arachidonate 5-lipoxygenase	Target Info	Antagonist	[551926]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Staphylococcus aureus infectionhsa00590:Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosis
NetPath Pathway	IL5 Signaling Pathway
	Leptin Signaling PathwayNetPath_16:IL4 Signaling Pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
Reactome	Class A/1 (Rhodopsin-like receptors)
	G alpha (q) signalling events
	Interferon gamma signaling
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	Interferon gamma signaling
	GPCR ligand binding
	GPCR downstream signalingWP2877:Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 545947	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005461)
Ref 551926	WO patent application no. 2002,01223,5, 1,4-dihydropyridines as bradykinin antagonists.

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