Drug Information

Drug General Information
Drug ID
D01MBV
Former ID
DNC001295
Drug Name
SB-207266A
Drug Type
Small molecular drug
Indication Irritable bowel syndrome [ICD9: 564.1, 787.91; ICD10:A09, K58, K59.1] Phase 2 [551422]
Structure
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2D MOL

3D MOL
Formula
C22H32ClN3O2
Canonical SMILES
CCCCN1CCC(CC1)CNC(=O)C2=C3N(CCCO3)C4=CC=CC=C42.Cl
InChI
1S/C22H31N3O2.ClH/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25;/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26);1H
InChIKey
UABVCZHWRUGYSR-UHFFFAOYSA-N
CAS Number
CAS 152811-62-6
PubChem Compound ID
177335
PubChem Substance ID
10258593, 12015016, 14757387, 33500789, 47207140, 52719579, 104426308, 125823267, 134340501, 135154835, 135697559, 160698229, 198988856, 223704834, 223935692, 228356724, 252159856
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Antagonist [535146]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 551422Clinical pipeline report, company report or official report of Department of Pharmacology University of Wisconsin School of Medicine.
Ref 535146Irritable bowel syndrome: new agents targeting serotonin receptor subtypes. Drugs. 2001;61(3):317-32.

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