Drug Information

Drug General Information
Drug ID
D01QKR
Former ID
DIB015579
Drug Name
ALNESPIRONE
Synonyms
S-20499; Alnespirone < Rec INN >; (+)-(S)-N-[4-[(5-Methoxy-3-chromanyl)propylamino]butyl]-1,1-cyclopentanediacetimide; (S)-(+)-8-[4-[N-(5-Methoxy-3,4-dihydro-2H-benzo[b]pyran-3-yl)-N-propylamino]butyl]-8-azaspiro[4.5]decane-7,9-dione
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Discontinued in Phase 2 [544887]
Structure
Download
2D MOL

3D MOL
Formula
C26H39ClN2O4
Canonical SMILES
CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)[C@@H]3COc4cccc(OC)c4C3
InChI
1S/C26H38N2O4/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26/h8-10,20H,3-7,11-19H2,1-2H3/t20-/m0/s1
InChIKey
DLLULNTXJPATBC-FQEVSTJZSA-N
CAS Number
CAS 138298-79-0
PubChem Compound ID
9826391
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [534835], [551871]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 544887Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001421)
Ref 534835Chronic alnespirone-induced desensitization of somatodendritic 5-HT1A autoreceptors in the rat dorsal raphe nucleus. Eur J Pharmacol. 1999 Jan 22;365(2-3):165-73.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.