Drug Information

Drug General Information
Drug ID
D01QUF
Former ID
DIB010693
Drug Name
GW-3600
Synonyms
Phosphodiesterase 4 inhibitor, Glaxo
Indication Asthma [ICD10:J45] Terminated [546122]
Company
GlaxoSmithKline Inc
Structure
Download
2D MOL

3D MOL
Canonical SMILES
N1(C(=O)OC)C[C@H]([C@@](C1)(OC)C)c1cc(OC2CCCC2)c(cc1)OC
CAS Number
CAS 173258-94-1
Target and Pathway
Target(s) Type IV phosphodiesterase Target Info Inhibitor [534617]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [534617]
CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [534617]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
TSH signaling pathwayWP35:G Protein Signaling Pathways
Nuclear Receptors Meta-Pathway
Opioid SignallingWP35:G Protein Signaling Pathways
References
Ref 546122Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006447)
Ref 534617Dual inhibition of human type 4 phosphodiesterase isostates by (R, R)-(+/-)-methyl 3-acetyl-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate. Biochemistry. 1998 May 12;37(19):6894-904.

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