Drug Information

Drug General Information
Drug ID
D01RNA
Former ID
DIB019718
Drug Name
desmosterol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539793]
Structure
Download
2D MOL
Formula
C27H44O
InChI
InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChIKey
AVSXSVCZWQODGV-DPAQBDIFSA-N
PubChem Compound ID
439577
PubChem Substance ID
4928, 4266377, 8144027, 10298383, 15978228, 24894033, 36883775, 52670367, 57394893, 57403092, 99300578, 103637422, 104620858, 126524635, 127466210, 135651470, 137237337, 138128789, 138613691, 162221242, 164815728, 179293074, 184544358, 198962901, 223703363, 224772242, 226520608, 252363923, 252551927, 252669467
Target and Pathway
Target(s) Oxysterols receptor LXR-beta Target Info Agonist [528328]
Farnesoid X receptor-beta Target Info Agonist [526511]
Oxysterols receptor LXR-alpha Target Info Agonist [528328]
KEGG Pathway PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome Nuclear Receptor transcription pathway
WikiPathways SREBP signalling
Nuclear ReceptorsWP299:Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear Receptors
References
Ref 539793(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2748).
Ref 526511Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. Mol Cell Biol. 2003 Feb;23(3):864-72.
Ref 528328Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem. 2006 Sep 22;281(38):27816-26. Epub 2006 Jul 20.

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