Drug Information

Drug General Information
Drug ID
D01RXM
Former ID
DNC000369
Drug Name
BZ3
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535762]
Structure
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2D MOL

3D MOL
Formula
C9H9NO
Canonical SMILES
COC1=CC2=C(C=C1)NC=C2
InChI
1S/C9H9NO/c1-11-8-2-3-9-7(6-8)4-5-10-9/h2-6,10H,1H3
InChIKey
DWAQDRSOVMLGRQ-UHFFFAOYSA-N
PubChem Compound ID
13872
PubChem Substance ID
481053, 590665, 954727, 3133797, 4580631, 8160457, 10502178, 15219189, 16956378, 24896650, 29198240, 29281985, 29621524, 37348378, 37416220, 49747989, 49747990, 49830099, 49984240, 50485552, 53795913, 57328368, 81091036, 85087592, 85248158, 85248164, 87572737, 87617445, 92709947, 93616689, 99214441, 103177917, 104332969, 104669740, 117498597, 117688446, 117715029, 125327801, 125336461, 126544581, 126572620, 126577787, 126593819, 126605827, 126607451, 126614971, 126632357, 126658504, 126668406, 126693609
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [535762]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 535762Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies. Clin Cancer Res. 2003 Jul;9(7):2711-8.
Ref 535762Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies. Clin Cancer Res. 2003 Jul;9(7):2711-8.

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