Drug General Information
Drug ID	D01SRS
Former ID	DNC004986
Drug Name	3-Methyl-7-nitro-1,2,3,4-tetrahydro-isoquinoline
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527414]
Structure		Download 2D MOL 3D MOL
Formula	C10H12N2O2
Canonical SMILES	CC1CC2=C(CN1)C=C(C=C2)[N+](=O)[O-]
InChI	1S/C10H12N2O2/c1-7-4-8-2-3-10(12(13)14)5-9(8)6-11-7/h2-3,5,7,11H,4,6H2,1H3
InChIKey	OTVSEAHLIUCIKT-UHFFFAOYSA-N
PubChem Compound ID	15407445
Target and Pathway
Target(s)	Alpha-2A adrenergic receptor	Target Info	Inhibitor	[527414]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 527414	Bioorg Med Chem Lett. 2005 Feb 15;15(4):1143-7.Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines.
Ref 527414	Bioorg Med Chem Lett. 2005 Feb 15;15(4):1143-7.Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines.

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