Drug Information

Drug General Information
Drug ID
D01TOR
Former ID
DNC011971
Drug Name
Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533684]
Structure
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2D MOL

3D MOL
Formula
C20H16N4
Canonical SMILES
C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)C4=CN=CC=C4
InChI
1S/C20H16N4/c1-2-7-15(8-3-1)13-22-20-17-10-4-5-11-18(17)23-19(24-20)16-9-6-12-21-14-16/h1-12,14H,13H2,(H,22,23,24)
InChIKey
AELMNLIYFALJIR-UHFFFAOYSA-N
PubChem Compound ID
667555
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [533684]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [533684]
CGMP-dependent3',5'-cyclic phosphodiesterase Target Info Inhibitor [533684]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
cGMP-PKG signaling pathway
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling PathwayNetPath_23:TSH Signaling Pathway
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling eventsR-HSA-418457:cGMP effects
G alpha (s) signalling events
WikiPathways G Protein Signaling PathwaysWP35:G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Nuclear Receptors Meta-Pathway
Opioid Signalling
References
Ref 533684J Med Chem. 1995 Sep 1;38(18):3547-57.Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities.
Ref 533684J Med Chem. 1995 Sep 1;38(18):3547-57.Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities.

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