Drug Information

Drug General Information
Drug ID
D01TYJ
Former ID
DNC005947
Drug Name
4-(4,6-dinitro-1H-indol-1-ylsulfonyl)benzenamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527760]
Structure
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2D MOL

3D MOL
Formula
C14H10N4O6S
Canonical SMILES
C1=CC(=CC=C1N)S(=O)(=O)N2C=CC3=C(C=C(C=C32)[N+](=O)[O-]<br />)[N+](=O)[O-]
InChI
1S/C14H10N4O6S/c15-9-1-3-11(4-2-9)25(23,24)16-6-5-12-13(16)7-10(17(19)20)8-14(12)18(21)22/h1-8H,15H2
InChIKey
NMGNRDGVTLTPFO-UHFFFAOYSA-N
PubChem Compound ID
44405257
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [527760]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 527760Bioorg Med Chem Lett. 2005 Dec 1;15(23):5298-302. Epub 2005 Sep 23.Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors.
Ref 527760Bioorg Med Chem Lett. 2005 Dec 1;15(23):5298-302. Epub 2005 Sep 23.Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors.

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