Drug Information

Drug General Information
Drug ID
D01URS
Former ID
DIB020684
Drug Name
PF-592379
Synonyms
PF-592,379
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542663]
Structure
Download
2D MOL
Formula
C13H21N3O
InChI
InChI=1S/C13H21N3O/c1-3-6-16-8-12(17-9-10(16)2)11-4-5-13(14)15-7-11/h4-5,7,10,12H,3,6,8-9H2,1-2H3,(H2,14,15)/t10-,12-/m0/s1
InChIKey
DFTCYTDJDXZFSK-JQWIXIFHSA-N
PubChem Compound ID
10263487
PubChem Substance ID
15267663, 22643166, 41248723, 80417724, 137017765, 141407201, 162223207, 223366018, 228013202, 248731985
Target and Pathway
Target(s) D(4) dopamine receptor Target Info Agonist [531866]
D(3) dopamine receptor Target Info Agonist [531866]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP58:Monoamine GPCRs
GPCRs, Other
References
Ref 542663(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7683).
Ref 531866Lack of abuse potential in a highly selective dopamine D3 agonist, PF-592,379, in drug self-administration and drug discrimination in rats. Behav Pharmacol. 2012 Jun;23(3):280-91.

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