Drug General Information
Drug ID	D01UVU
Former ID	DNC014890
Drug Name	4-(3-bromopyrazolo[1,5-a]pyrimidin-6-yl)phenol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531199]
Structure		Download 2D MOL 3D MOL
Formula	C12H8BrN3O
Canonical SMILES	C1=CC(=CC=C1C2=CN3C(=C(C=N3)Br)N=C2)O
InChI	1S/C12H8BrN3O/c13-11-6-15-16-7-9(5-14-12(11)16)8-1-3-10(17)4-2-8/h1-7,17H
InChIKey	XBHIAJWNXVJSAA-UHFFFAOYSA-N
PubChem Compound ID	52947893
Target and Pathway
Target(s)	AMP-activated protein kinase	Target Info	Inhibitor	[531199]
KEGG Pathway	FoxO signaling pathway
	Regulation of autophagy
	mTOR signaling pathway
	PI3K-Akt signaling pathway
	AMPK signaling pathway
	Circadian rhythm
	Insulin signaling pathway
	Adipocytokine signaling pathway
	Oxytocin signaling pathway
	Glucagon signaling pathway
	Non-alcoholic fatty liver disease (NAFLD)
	Hypertrophic cardiomyopathy (HCM)
Reactome	Translocation of GLUT4 to the plasma membrane
	Macroautophagy
	Activation of PPARGC1A (PGC-1alpha) by phosphorylation
	TP53 Regulates Metabolic Genes
WikiPathways	Insulin Signaling
	Energy dependent regulation of mTOR by LKB1-AMPK
	JAK/STAT
	BDNF signaling pathway
	Leptin signaling pathway
	SREBF and miR33 in cholesterol and lipid homeostasis
	SREBP signalling
	Signaling by Insulin receptor
	TOR Signaling
	AMPK Signaling
References
Ref 531199	Bioorg Med Chem Lett. 2010 Nov 15;20(22):6394-9. Epub 2010 Sep 19.The rational design of a novel potent analogue of the 5'-AMP-activated protein kinase inhibitor compound C with improved selectivityand cellular activity.
Ref 531199	Bioorg Med Chem Lett. 2010 Nov 15;20(22):6394-9. Epub 2010 Sep 19.The rational design of a novel potent analogue of the 5'-AMP-activated protein kinase inhibitor compound C with improved selectivityand cellular activity.

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