Drug Information

Drug General Information
Drug ID
D01VAB
Former ID
DAP000941
Drug Name
Alprenolol
Synonyms
Alfeprol; Alpheprol; Alprenololum; Yobir; Alfeprol [Russian]; Alprenolol (INN); Alprenolol [INN:BAN]; Alprenololum [INN-Latin]; Apllobal (TN); Aptine (TN); Aptol (TN); Duriles (TN); Gubernal (TN); Regletin (TN); Yobir (TN); H-56-28; 1-(2-Allylphenoxy)-3-isopropylamino-2-propanol; 1-(o-Allylphenoxy)-3-(isopropylamino)-2-propanol; 1-(o-Allylphenoxy)-3-isopropylamino)-2-propanol; 1-(propan-2-ylamino)-3-(2-prop-2-enylphenoxy)propan-2-ol; 1-[2-(propen-2-ylphenoxy)]-3-(isopropylamino)propan-2-ol
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Withdrawn from market [540993], [550781]
Therapeutic Class
Antiarrhythmic Agents
Company
AstraZeneca
Structure
Download
2D MOL

3D MOL
Formula
C15H23NO2
InChI
InChI=1S/C15H23NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3
InChIKey
PAZJSJFMUHDSTF-UHFFFAOYSA-N
CAS Number
CAS 13655-52-2
PubChem Compound ID
2119
PubChem Substance ID
7403854, 8151437, 10507180, 11335190, 11360429, 11363062, 11365624, 11368186, 11371971, 11374790, 11376348, 11461401, 11466278, 11467398, 11485563, 11485995, 11489630, 11490881, 11493030, 11493982, 11534311, 15044941, 26752306, 29221299, 46506033, 47290959, 47440065, 47736281, 47810579, 47810580, 47885235, 48034925, 48034926, 48184817, 49698847, 50022618, 50105225, 50105226, 51091495, 56413052, 57321152, 80044758, 85209662, 85788463, 90340777, 92308802, 96099927, 103164453, 103852444, 104171111
ChEBI ID
ChEBI:31191
SuperDrug ATC ID
C07AA01
SuperDrug CAS ID
cas=013655522
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Antagonist [534890], [536850]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathy
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 540993(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 563).
Ref 550781Drug information of Alprenolol, 2008. eduDrugs.
Ref 534890Inverse agonist activities of beta-adrenoceptor antagonists in rat myocardium. Br J Pharmacol. 1999 Jun;127(4):895-902.
Ref 536850Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14555-60. Epub 2008 Sep 11.

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