Drug Information

Drug General Information
Drug ID
D01XUE
Former ID
DNCL003059
Drug Name
Tedatioxetine
Drug Type
Small molecular drug
Indication Generalized anxiety disorder; Major depressive disorder [ICD9: 300, 300.02, 311, 296.2, 296.3, 710.0; ICD10:F32, F40-F42, F41.1, F33, M32] Phase 1 [548243]
Company
Lundbeck; Takeda Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C18H21NS
Canonical SMILES
CC1=CC=C(C=C1)SC2=CC=CC=C2C3CCNCC3
InChI
1S/C18H21NS/c1-14-6-8-16(9-7-14)20-18-5-3-2-4-17(18)15-10-12-19-13-11-15/h2-9,15,19H,10-13H2,1H3
InChIKey
CVASBKDYSQKLSO-UHFFFAOYSA-N
CAS Number
CAS 508233-95-2
PubChem Compound ID
9878913
PubChem Substance ID
14844912, 24166836, 45625870, 76531516, 135268546, 135626888, 137048306, 137939927, 160681858, 162224025, 198949367, 226856655, 244688475
Target and Pathway
Target(s) 5-HT 3 receptor Target Info Modulator [1572591]
5-hydroxytryptamine 2C receptor Target Info Modulator [1572591]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 548243Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023694)
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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