Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01XWG
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| Former ID |
DAP000788
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| Drug Name |
Daunorubicin
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| Synonyms |
Acetyladriamycin; Anthracyline; Cerubidin; Cerubidine; Daunamycin; Daunarubicinum; DaunoXome; Daunoblastin; Daunoblastine; Daunomycin; Daunorrubicina; Daunorubicine; Daunorubicinum; Rubidomycin; Rubomycin; Antibiotics from Streptomyces coeruleorubidus; DAUNORUBICIN HCL; Leukaemomycin C; Rubomycin C; DM1; FI 6339; FI6339; RP 13057; Dauno-Rubidomycine; DaunoXome (TN); Daunorubicin (INN); Daunorubicin (liposomal); Daunorubicin [INN:BAN]; Daunorubicin, Hydrochloride; Daunorubicinum [INN-Latin]; VS-103; (+)-Daunomycin; (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-(methyloxy)-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside; (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranoside; (7S,9R)-9-Acetyl-7-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-oxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione; (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione; (8S-cis)-8-Acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione; (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Anticancer Agents
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| Structure |
|
Download2D MOL |
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| Formula |
C27H29NO10
|
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| InChI |
InChI=1S/C27H29NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3/t10-,14-,16-,17-,22+,27-/m0/s1
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| InChIKey |
STQGQHZAVUOBTE-VGBVRHCVSA-N
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| CAS Number |
CAS 20830-81-3
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| PubChem Compound ID | |||||
| PubChem Substance ID |
5016, 596008, 866161, 7887073, 7979028, 8171488, 11114094, 14763056, 15481415, 24769892, 26697306, 26701813, 26704223, 26715132, 26718351, 26718779, 29215022, 34672588, 46508433, 47440436, 47736668, 48110630, 48415843, 49699346, 49855159, 50070917, 50104250, 53788227, 56465013, 57288764, 57310919, 74382025, 74462219, 85788867, 92307396, 92308820, 96024474, 103477782, 104066339, 104307942, 117393873, 124766118, 124886869, 124886870, 124886871, 125299287, 126663226, 127301039, 127301040, 127301041
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| ChEBI ID |
ChEBI:41977
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| SuperDrug ATC ID |
L01DB02
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| SuperDrug CAS ID |
cas=020830813
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| Drug Resistance Mutation (DRM) | |||||
| DRM | DRM Info | ||||
| Target and Pathway | |||||
| Target(s) | DNA topoisomerase II | Target Info | Modulator | [556264] | |
| References | |||||
| Ref 536361 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. | ||||
| Ref 542069 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7063). | ||||
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