Drug General Information
Drug ID	D01YDF
Former ID	DIB015753
Drug Name	Pibutidine
Synonyms	Alex; Pibutidine hydrochloride; IT-066
Drug Type	Small molecular drug
Indication	Ulcerative colitis [ICD9: 556; ICD10:K51]		Discontinued in Phase 3	[544697]
Company	Ikeda Mohando Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C19H24N4O3
Canonical SMILES	C1(=C(C(=O)C1=O)N)NC/C=C\COc1nccc(CN2CCCCC2)c1.Cl
PubChem Compound ID	5282450
Target and Pathway
Target(s)	Histamine H2 receptor	Target Info	Modulator	[533592]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gastric acid secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway	Intracellular Signalling Through Histamine H2 Receptor and Histamine
	Gastric Acid Production
Reactome	Histamine receptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544697	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000641)
Ref 533592	Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors. Mol Pharmacol. 1995 Oct;48(4):774-82.

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