Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02AYI
|
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| Former ID |
DNC009583
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| Drug Name |
2-(4-phenoxyphenoxy)ethanamine
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [529868] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C14H15NO2
|
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| Canonical SMILES |
C1=CC=C(C=C1)OC2=CC=C(C=C2)OCCN
|
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| InChI |
1S/C14H15NO2/c15-10-11-16-12-6-8-14(9-7-12)17-13-4-2-1-3-5-13/h1-9H,10-11,15H2
|
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| InChIKey |
FBLANPWAVFBRNS-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Phospholipase A2, membrane associated | Target Info | Inhibitor | [529868] | |
| Leukotriene A-4 hydrolase | Target Info | Inhibitor | [529770] | ||
| BioCyc Pathway | PhospholipasesPWY66-375:Leukotriene biosynthesis | ||||
| KEGG Pathway | Glycerophospholipid metabolism | ||||
| Ether lipid metabolism | |||||
| Arachidonic acid metabolism | |||||
| Linoleic acid metabolism | |||||
| alpha-Linolenic acid metabolism | |||||
| Metabolic pathways | |||||
| Ras signaling pathway | |||||
| Vascular smooth muscle contraction | |||||
| Pancreatic secretion | |||||
| Fat digestion and absorptionhsa00590:Arachidonic acid metabolism | |||||
| Pathway Interaction Database | Glypican 1 network | ||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| References | |||||
| Ref 529770 | Bioorg Med Chem Lett. 2008 Dec 15;18(24):6549-52. Epub 2008 Oct 14.Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives. | ||||
| Ref 529868 | J Med Chem. 2008 Dec 25;51(24):7882-8.Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching. | ||||
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