Drug General Information
Drug ID	D02BPV
Former ID	DNC012811
Drug Name	5-(2-Amino-ethyl)-2-chloro-phenol hydrobromide
Indication	Discovery agent		Investigative	[526782]
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C1=CC(=C(C=C1CCN)O)Cl
InChI	1S/C8H10ClNO/c9-7-2-1-6(3-4-10)5-8(7)11/h1-2,5,11H,3-4,10H2
InChIKey	PMBDMPWZYMGZDT-UHFFFAOYSA-N
Target and Pathway
Target(s)	Dopamine D1 receptor	Target Info	Inhibitor	[526782]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Amphetamine addiction
	Morphine addiction
	Alcoholism
PANTHER Pathway	Dopamine receptor mediated signaling pathway
PathWhiz Pathway	Dopamine Activation of Neurological Reward System
Reactome	Dopamine receptors
	G alpha (s) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 526782	J Med Chem. 1992 Nov 13;35(23):4408-14.Synthesis and pharmacological characterization of 2-(4-chloro-3-hydroxyphenyl)ethylamine and N,N-dialkyl derivatives as dopamine receptor ligands.
Ref 526782	J Med Chem. 1992 Nov 13;35(23):4408-14.Synthesis and pharmacological characterization of 2-(4-chloro-3-hydroxyphenyl)ethylamine and N,N-dialkyl derivatives as dopamine receptor ligands.

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