Drug General Information
Drug ID	D02BUW
Former ID	DNC004149
Drug Name	2-(3,4,5-Trihydroxy-benzylidene)-malononitrile
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533795]
Structure		Download 2D MOL 3D MOL
Formula	C10H6N2O3
Canonical SMILES	C1=C(C=C(C(=C1O)O)O)C=C(C#N)C#N
InChI	1S/C10H6N2O3/c11-4-7(5-12)1-6-2-8(13)10(15)9(14)3-6/h1-3,13-15H
InChIKey	YZOFLYUAQDJWKV-UHFFFAOYSA-N
PubChem Compound ID	2061
Target and Pathway
Target(s)	Lck tyrosine kinase	Target Info	Inhibitor	[533795]
KEGG Pathway	NF-kappa B signaling pathway
	Osteoclast differentiation
	Natural killer cell mediated cytotoxicity
	T cell receptor signaling pathway
	HTLV-I infection
	Primary immunodeficiency
NetPath Pathway	TCR Signaling Pathway
	IL2 Signaling Pathway
PANTHER Pathway	Parkinson disease
	T cell activation
Pathway Interaction Database	Atypical NF-kappaB pathway
	Glypican 1 network
	TCR signaling in na&#xef
	Signaling events mediated by PTP1B
	IL12-mediated signaling events
	Regulation of p38-alpha and p38-beta
	TCR signaling in na&#xef
	Thromboxane A2 receptor signaling
	SHP2 signaling
	IL2-mediated signaling events
	CXCR4-mediated signaling events
	Class I PI3K signaling events
	IL2 signaling events mediated by PI3K
	amb2 Integrin signaling
	EPHA forward signaling
	PDGFR-beta signaling pathway
	IL2 signaling events mediated by STAT5
	Ephrin B reverse signaling
	Alpha-synuclein signaling
Reactome	GPVI-mediated activation cascade
	PIP3 activates AKT signaling
	Regulation of KIT signaling
	Phosphorylation of CD3 and TCR zeta chains
	Translocation of ZAP-70 to Immunological synapse
	Generation of second messenger molecules
	PECAM1 interactions
	Constitutive Signaling by Aberrant PI3K in Cancer
	DAP12 signaling
	CD28 co-stimulation
	CD28 dependent PI3K/Akt signaling
	CD28 dependent Vav1 pathway
	CTLA4 inhibitory signaling
	PD-1 signaling
	Interleukin-2 signaling
WikiPathways	Notch Signaling Pathway
	Interferon type I signaling pathways
	IL-2 Signaling Pathway
	Inflammatory Response Pathway
	Signaling by SCF-KIT
	DAP12 interactions
	Host Interactions of HIV factors
	PIP3 activates AKT signaling
	T-Cell Receptor and Co-stimulatory Signaling
	B Cell Receptor Signaling Pathway
	TSLP Signaling Pathway
	TCR signaling
	Costimulation by the CD28 family
References
Ref 533795	J Med Chem. 1993 Nov 12;36(23):3556-64.Tyrphostins. 3. Structure-activity relationship studies of alpha-substituted benzylidenemalononitrile 5-S-aryltyrphostins.
Ref 533795	J Med Chem. 1993 Nov 12;36(23):3556-64.Tyrphostins. 3. Structure-activity relationship studies of alpha-substituted benzylidenemalononitrile 5-S-aryltyrphostins.

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