Drug Information

Drug General Information
Drug ID
D02CFR
Former ID
DIB006237
Drug Name
GW-559768X
Synonyms
GW-559768X; GW-569998X; GW-578257A; GW-585550A; RET tyrosine kinase inhibitors (cancer); RET tyrosine kinase inhibitors (cancer), GlaxoSmithKline
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543572]
Company
GlaxoSmithKline plc
Structure
Download
2D MOL

3D MOL
Canonical SMILES
O=S(=O)(c1ccc2c(c1)c(ccn2)Nc1c(cc(c(c1)O)F)O)C
Target and Pathway
Target(s) Proto-oncogene tyrosine-protein kinase receptor ret Target Info Inhibitor [543572]
KEGG Pathway Endocytosis
Pathways in cancer
Thyroid cancer
Central carbon metabolism in cancer
Pathway Interaction Database Signaling events regulated by Ret tyrosine kinase
Posttranslational regulation of adherens junction stability and dissassembly
WikiPathways SIDS Susceptibility Pathways
Dopaminergic Neurogenesis
References
Ref 543572(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2185).
Ref 543572(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2185).

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