Drug Information

Drug General Information
Drug ID
D02CPV
Former ID
DNC000087
Drug Name
5-Hydroxyeicosatetraenoic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535027], [538140]
Structure
Download
2D MOL
Formula
C20H32O3
Canonical SMILES
CCCCCC=CCC=CCC=CC=CC(CCCC(=O)O)O
InChI
1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16,19,21H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
InChIKey
KGIJOOYOSFUGPC-JGKLHWIESA-N
CAS Number
CAS 72255-35-7
PubChem Compound ID
5280733
PubChem Substance ID
7367, 4266109, 8616380, 14717639, 15469964, 26754739, 26754740, 39289780, 47290863, 47364900, 47364901, 49964846, 50110766, 53788764, 57357855, 77570786, 92309859, 99300773, 99302291, 103419145, 103936995, 104046382, 113853892, 126529724, 134339618, 135111503, 135651416, 137008431, 142970226, 164789588, 179205486, 184568140, 227683983, 249492905, 252371371, 252455583, 252465535
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [535027], [538140]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 535027Preview of potential therapeutic applications of leukotriene B4 inhibitors in dermatology. Skin Pharmacol Appl Skin Physiol. 2000 Sep-Oct;13(5):235-45.
Ref 538140Cellular oxygenation of 12-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid by 5-lipoxygenase is stimulated by 5-lipoxygenase-activating protein. J Biol Chem. 1998 Dec 4;273(49):32842-7.
Ref 535027Preview of potential therapeutic applications of leukotriene B4 inhibitors in dermatology. Skin Pharmacol Appl Skin Physiol. 2000 Sep-Oct;13(5):235-45.
Ref 538140Cellular oxygenation of 12-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid by 5-lipoxygenase is stimulated by 5-lipoxygenase-activating protein. J Biol Chem. 1998 Dec 4;273(49):32842-7.

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