Drug General Information
Drug ID	D02CSU
Former ID	DNC004706
Drug Name	4-Indan-(1Z)-ylidenemethyl-pyridine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527456]
Structure		Download 2D MOL 3D MOL
Formula	C15H13N
Canonical SMILES	C1CC(=CC2=CC=NC=C2)C3=CC=CC=C31
InChI	1S/C15H13N/c1-2-4-15-13(3-1)5-6-14(15)11-12-7-9-16-10-8-12/h1-4,7-11H,5-6H2/b14-11-
InChIKey	ZHGWOEHABOMOSV-KAMYIIQDSA-N
PubChem Compound ID	6539786
Target and Pathway
Target(s)	Cytochrome P450 11B1, mitochondrial	Target Info	Inhibitor	[527456]
	17 alpha-hydroxylase-C17, 20-lyase	Target Info	Inhibitor	[527456]
	Cytochrome P450 19	Target Info	Inhibitor	[527456]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Glucocorticoid biosynthesis
	Mineralocorticoid biosynthesisPWY-7305:Superpathway of steroid hormone biosynthesis
	Androgen biosynthesisPWY-7305:Superpathway of steroid hormone biosynthesis
	Estradiol biosynthesis II
	Estradiol biosynthesis I
KEGG Pathway	Steroid hormone biosynthesis
	Metabolic pathwayshsa00140:Steroid hormone biosynthesis
	Metabolic pathways
	Ovarian steroidogenesis
	Prolactin signaling pathwayhsa00140:Steroid hormone biosynthesis
NetPath Pathway	FSH Signaling Pathway
PANTHER Pathway	Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway	SteroidogenesisPW000045:Androgen and Estrogen Metabolism
Reactome	Glucocorticoid biosynthesis
	Endogenous sterolsR-HSA-193048:Androgen biosynthesis
	Endogenous sterolsR-HSA-211976:Endogenous sterols
WikiPathways	Metapathway biotransformation
	Oxidation by Cytochrome P450
	Metabolism of steroid hormones and vitamin D
	Corticotropin-releasing hormoneWP702:Metapathway biotransformation
	Steroid Biosynthesis
	Glucocorticoid & Mineralcorticoid Metabolism
	Prostate Cancer
	Phase 1 - Functionalization of compoundsWP702:Metapathway biotransformation
	Tryptophan metabolism
	Ovarian Infertility Genes
	FSH signaling pathway
	Integrated Breast Cancer Pathway
	Phase 1 - Functionalization of compounds
References
Ref 527456	J Med Chem. 2005 Mar 10;48(5):1563-75.Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.
Ref 527456	J Med Chem. 2005 Mar 10;48(5):1563-75.Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.

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