Drug Information

Drug General Information
Drug ID
D02DMQ
Former ID
DAP000008
Drug Name
Eletriptan
Synonyms
Eletriptanum; Relpax; UK 116044; UK116044; Eletriptan (INN); Eletriptan [INN:BAN]; Relpax (TN); UK-116044; UK-116044-04; (R)-3-[(1-Methyl-2-pyrrolidinyl)methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-Indole; (R)-5-[2-(Benzenesulfonyl)ethyl]-3-[(N-methylpyrrolidin-2-yl)methyl]-1H-indole; 3-(((R)-1-Methyl-2-pyrrolidinyl)methyl)-5-(2-(phenylsulfonyl)ethyl)indole; 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1H-indole; 5-[2-(benzenesulfonyl)ethyl]-3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-1H-indole
Drug Type
Small molecular drug
Indication Migraine [ICD9: 346; ICD10:G43] Approved [536361], [540615]
Therapeutic Class
Antimigraine Agents
Company
Pfizer Inc
Structure
Download
2D MOL

3D MOL
Formula
C22H26N2O2S
InChI
InChI=1S/C22H26N2O2S/c1-24-12-5-6-19(24)15-18-16-23-22-10-9-17(14-21(18)22)11-13-27(25,26)20-7-3-2-4-8-20/h2-4,7-10,14,16,19,23H,5-6,11-13,15H2,1H3/t19-/m1/s1
InChIKey
PWVXXGRKLHYWKM-LJQANCHMSA-N
CAS Number
CAS 143322-58-1
PubChem Compound ID
77993
PubChem Substance ID
8199306, 12014973, 14829466, 14927226, 43133578, 46506380, 50070538, 50071173, 50125841, 50462554, 53790006, 56394955, 92720041, 96024583, 103558413, 104368729, 109693042, 121264533, 126620364, 126652688, 126667007, 128979846, 134337338, 135035470, 135650227, 137002442, 142037588, 144206290, 151990438, 160963564, 163134331, 164814960, 170465317, 175265777, 175437670, 179149922, 196108133, 198993164, 223554905, 223659237, 223824718, 226414505, 249804705, 251916767, 251918006, 252215339
ChEBI ID
ChEBI:50922
SuperDrug ATC ID
N02CC06
SuperDrug CAS ID
cas=143322581
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Modulator [556264]
5-hydroxytryptamine 1D receptor Target Info Modulator [556264]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 540615(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 40).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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