Drug Information

Drug General Information
Drug ID
D02DPU
Former ID
DNC002665
Drug Name
Aniracetam
Drug Type
Small molecular drug
Indication Cerebrovascular ischaemia [ICD9: 434.91; ICD10:I61-I63] Approved [467478], [526084]
Structure
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2D MOL

3D MOL
Formula
C12H13NO3
InChI
InChI=1S/C12H13NO3/c1-16-10-6-4-9(5-7-10)12(15)13-8-2-3-11(13)14/h4-7H,2-3,8H2,1H3
InChIKey
ZXNRTKGTQJPIJK-UHFFFAOYSA-N
CAS Number
CAS 72432-10-1
PubChem Compound ID
2196
PubChem Substance ID
586099, 855554, 856168, 866709, 5141621, 7848945, 7885359, 7978709, 8149895, 8151490, 11110806, 11113324, 11335578, 11360817, 11364236, 11366798, 11369360, 11372625, 11374281, 11377522, 11461789, 11491368, 11492576, 11495156, 12012619, 15195914, 17404678, 24277955, 26612390, 26746909, 26751447, 29221374, 46506607, 46530484, 47216709, 47216710, 47515250, 47736407, 47736408, 48259164, 49834898, 50039822, 50085875, 50100176, 50103913, 50103914, 53777221, 53790416, 57321194, 79402177
SuperDrug ATC ID
N06BX11
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Inhibitor [551390]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [551390]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04020:Calcium signaling pathway
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic NeuronsWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
GPCRs, Other
References
Ref 467478(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4133).
Ref 526084Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. Eur J Pharmacol. 2001 May 18;420(1):33-43.
Ref 551390Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. Eur J Pharmacol. 2001 May 18;420(1):33-43.

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