Drug Information

Drug General Information
Drug ID
D02DSZ
Former ID
DNAP001417
Drug Name
Temocapril hydrochloride
Synonyms
Acecol (TN)
Drug Type
Small molecular drug
Indication Cardiovascular disorder [ICD10:I00-I99] Approved [551871]
Company
Sankyo
Structure
Download
2D MOL

3D MOL
Formula
C23H29ClN2O5S2
Canonical SMILES
CCOC(=O)C(CCC1=CC=CC=C1)NC2CSC(CN(C2=O)CC(=O)O)C3=CC=CS<br />3.Cl
InChI
1S/C23H28N2O5S2.ClH/c1-2-30-23(29)17(11-10-16-7-4-3-5-8-16)24-18-15-32-20(19-9-6-12-31-19)13-25(22(18)28)14-21(26)27;/h3-9,12,17-18,20,24H,2,10-11,13-15H2,1H3,(H,26,27);1H/t17-,18-,20-;/m0./s1
InChIKey
XDDQNOKKZKHBIX-ASBZXGSUSA-N
CAS Number
CAS 111902-57-9
PubChem Compound ID
443873
PubChem Substance ID
7848182, 10299418, 12014034, 14836097, 36887058, 49830338, 50125938, 57404542, 79973872, 85177334, 91748956, 92719255, 104630903, 118843683, 125001891, 126620952, 126652171, 136376497, 144206356, 152034675, 152254723, 160687099, 164234043, 164826268, 165239301, 170465944, 170539126, 174476450, 175427114, 196111929, 198940811, 210279530, 210281853, 226492861, 242601228, 252301088, 252356963, 252429416
SuperDrug ATC ID
C09AA14
Target and Pathway
Target(s) Angiotensin-converting enzyme Target Info Modulator [534314], [536361]
KEGG Pathway Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 534314Natural products in drug discovery and development. J Nat Prod. 1997 Jan;60(1):52-60.
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.

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