Drug Information

Drug General Information
Drug ID
D02DVB
Former ID
DIB008455
Drug Name
AGN-191743
Indication Allergy [ICD9: 995.3; ICD10:T78.4] Discontinued in Phase 1 [545538]
Company
Roche Holding AG
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Modulator [550918]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 545538Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003636)
Ref 550918US patent application no. 6,274,627, Conjugates of dithiocarbamate disulfides with pharmacologically active agents and uses therefor.

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