Drug Information

Drug General Information
Drug ID
D02ECA
Former ID
DNC002893
Drug Name
PF-00356231
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551391]
Structure
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2D MOL

3D MOL
Formula
C25H20N2O3S
Canonical SMILES
C1=CC=C(C=C1)C(CC(=O)O)NC(=O)C2=CC(=CS2)C3=CC=C(C=C3)C4<br />=CC=NC=C4
InChI
1S/C25H20N2O3S/c28-24(29)15-22(20-4-2-1-3-5-20)27-25(30)23-14-21(16-31-23)18-8-6-17(7-9-18)19-10-12-26-13-11-19/h1-14,16,22H,15H2,(H,27,30)(H,28,29)/t22-/m1/s1
InChIKey
VMTJQZUZINLEKC-JOCHJYFZSA-N
PubChem Compound ID
448942
PubChem Substance ID
585485, 7889802, 10300271, 16503381, 36890642, 46393341, 46504539, 79111597, 103626955, 104112689, 104640173, 135697734, 142580077, 143270595, 160966497, 233824761, 241142146, 246317472, 252159934
Target and Pathway
Target(s) MMP-12 Target Info Inhibitor [551391]
NetPath Pathway IL1 Signaling Pathway
IL5 Signaling Pathway
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
WikiPathways TGF beta Signaling Pathway
Degradation of collagen
Matrix Metalloproteinases
References
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January

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