Drug Information

Drug General Information
Drug ID
D02EIB
Former ID
DNC008940
Drug Name
4-(Spiro[chromene-2,4'-piperidine]-4-yl)phenol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529689]
Structure
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2D MOL

3D MOL
Formula
C19H19NO2
Canonical SMILES
C1CNCCC12C=C(C3=CC=CC=C3O2)C4=CC=C(C=C4)O
InChI
1S/C19H19NO2/c21-15-7-5-14(6-8-15)17-13-19(9-11-20-12-10-19)22-18-4-2-1-3-16(17)18/h1-8,13,20-21H,9-12H2
InChIKey
OZOVJRMTVPPLSS-UHFFFAOYSA-N
PubChem Compound ID
25129433
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Inhibitor [529689]
Delta-type opioid receptor Target Info Inhibitor [529689]
Mu-type opioid receptor Target Info Inhibitor [529689]
Potassium voltage-gated channel subfamily H member 2 Target Info Inhibitor [529689]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway Interaction Database IL4-mediated signaling events
PathWhiz Pathway Muscle/Heart Contraction
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-1296072:Voltage gated Potassium channels
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signalingWP69:TCR Signaling Pathway
Opioid Signalling
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Potassium Channels
References
Ref 529689J Med Chem. 2008 Oct 9;51(19):5893-6. Epub 2008 Sep 13.Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).
Ref 529689J Med Chem. 2008 Oct 9;51(19):5893-6. Epub 2008 Sep 13.Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).

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