Drug Information

Drug General Information
Drug ID
D02EMR
Former ID
DCL000752
Drug Name
Cilomilast
Synonyms
Ariflo; CIO; SB 207499; SB207499; Ariflo (TN); Cilomilast [USAN:INN]; SB-207499; Ariflo, SB-207499,Cilomilast; Cilomilast (JAN/USAN/INN); CIS-4-CYANO-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]CYCLOHEXANECARBOXYLIC ACID; Cis-4-Cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexanecarboxylic acid; Cis-4-Cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)cyclohexanecarboxylic acid; Cis-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-4-cyanocyclohexane-1-carboxylic acid; 4-cyano-4-(3-cyclopentoxy-4-methoxy-phenyl)-cyclohexane-1-carboxylic acid; 4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylic acid
Drug Type
Small molecular drug
Indication Emphysema; Bronchitis; Chronic obstructive pulmonary disease [ICD9: 460-519, 466, 490, 490-492, 491, 492, 494-496; ICD10:J00-J99, J20-J21, J40-J44, J42, J43, J47] Discontinued in Phase 3 [536958], [542430]
Asthma; Chronic obstructive pulmonary disease [ICD9: 490-492, 493, 494-496; ICD10:J40-J44, J47, J45] Discontinued in Phase 2 [536958], [542430]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C20H25NO4
InChI
InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23)/t14-,20-
InChIKey
CFBUZOUXXHZCFB-OYOVHJISSA-N
CAS Number
CAS 153259-65-5
PubChem Compound ID
151170
PubChem Substance ID
7848767, 7886612, 10251041, 12014847, 14827338, 14900458, 15722497, 40967267, 40967286, 46227735, 46393565, 46393575, 46505062, 46515098, 47657134, 48105226, 49957697, 50112773, 53790097, 57347308, 80059282, 93308090, 93310591, 99437274, 103587454, 103994769, 104430347, 124757262, 125164066, 125536625, 127615918, 127615919, 127615920, 131300126, 131349019, 131480881, 134339242, 135106954, 136367428, 136367988, 137102438, 137246277, 140119543, 141754319, 141948760, 144115831, 144206070, 152106616, 152258266, 152344295
Target and Pathway
Target(s) PDE4 Target Info Inhibitor [536223]
CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [536958]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addiction
Reactome DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling Pathways
References
Ref 536958Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53.
Ref 542430(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7407).
Ref 536223Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
Ref 536958Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53.

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