TTD | Drug: D02FMN

Drug General Information
Drug ID	D02FMN
Former ID	DIB020873
Drug Name	RXP-407
Synonyms	RXP 407
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[542819]
Structure		Download 2D MOL
Formula	C21H31N4O8P
InChI	InChI=1S/C21H31N4O8P/c1-12(20(30)23-13(2)19(22)29)11-34(32,33)17(9-15-7-5-4-6-8-15)25-21(31)16(10-18(27)28)24-14(3)26/h4-8,12-13,16-17H,9-11H2,1-3H3,(H2,22,29)(H,23,30)(H,24,26)(H,25,31)(H,27,28)(H,32,33)/t12-,13+,16+,17-/m1/s1
InChIKey	OCAZUTUOYLAIOA-OSRSDYAFSA-N
PubChem Compound ID	9827219
PubChem Substance ID	14786417, 14810828, 24129364, 44925350, 75878577, 93578001, 99303037, 104251912, 163342237, 223366217
Target and Pathway
Target(s)	Angiotensin-converting enzyme	Target Info	Inhibitor	[531920]
KEGG Pathway	Renin-angiotensin system
	Chagas disease (American trypanosomiasis)
	Hypertrophic cardiomyopathy (HCM)
PathWhiz Pathway	Angiotensin Metabolism
Reactome	Metabolism of Angiotensinogen to Angiotensins
WikiPathways	ACE Inhibitor Pathway
WikiPathways	Metabolism of Angiotensinogen to Angiotensins
References
Ref 542819	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7894).
Ref 531920	New ketomethylene inhibitor analogues: synthesis and assessment of structural determinants for N-domain selective inhibition of angiotensin-converting enzyme. Biol Chem. 2012 May;393(6):485-93.

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Drug Information