Drug General Information
Drug ID	D02FPF
Former ID	DNC008339
Drug Name	JUGLONE
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529353]
Structure		Download 2D MOL 3D MOL
Formula	C10H6O3
Canonical SMILES	C1=CC2=C(C(=O)C=CC2=O)C(=C1)O
InChI	1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H
InChIKey	KQPYUDDGWXQXHS-UHFFFAOYSA-N
PubChem Compound ID	3806
Target and Pathway
Target(s)	Dual specificity protein phosphatase 1	Target Info	Inhibitor	[529817]
	Arachidonate 5-lipoxygenase	Target Info	Inhibitor	[534507]
	M-phase inducer phosphatase 2	Target Info	Inhibitor	[529817]
	Indoleamine 2,3-dioxygenase	Target Info	Inhibitor	[529353]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesisPWY66-401:Superpathway of tryptophan utilization
	Tryptophan degradation
	L-kynurenine degradation
	Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
	NAD de novo biosynthesis
KEGG Pathway	MAPK signaling pathway
	Serotonergic synapsehsa00590:Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosishsa04010:MAPK signaling pathway
	Cell cycle
	Progesterone-mediated oocyte maturation
	MicroRNAs in cancerhsa00380:Tryptophan metabolism
	African trypanosomiasis
NetPath Pathway	FSH Signaling Pathway
	IL2 Signaling Pathway
	EGFR1 Signaling Pathway
	Wnt Signaling Pathway
	TCR Signaling PathwayNetPath_16:IL4 Signaling PathwayNetPath_14:IL2 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	Wnt Signaling PathwayNetPath_24:TSLP Signaling Pathway
	IL5 Signaling Pathway
Pathway Interaction Database	Fc-epsilon receptor I signaling in mast cells
	Regulation of p38-alpha and p38-beta
	Direct p53 effectors
	ErbB1 downstream signaling
	ATF-2 transcription factor network
	AP-1 transcription factor networkplk1_pathway:PLK1 signaling events
	FOXM1 transcription factor network
	p38 signaling mediated by MAPKAP kinases
	Aurora A signaling
PathWhiz Pathway	Arachidonic Acid MetabolismPW000163:Tryptophan Metabolism
Reactome	RAF-independent MAPK1/3 activation
	Negative regulation of MAPK pathwayR-HSA-157881:Cyclin B2 mediated events
	Cyclin A/B1 associated events during G2/M transition
	Cyclin A:Cdk2-associated events at S phase entryR-HSA-71240:Tryptophan catabolism
WikiPathways	MAPK Signaling PathwayWP2877:Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient NetworkWP615:Senescence and Autophagy in Cancer
	MAPK Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Prostate Cancer
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Mitotic G2-G2/M phases
	Cell CycleWP465:Tryptophan metabolism
	Metabolism of amino acids and derivatives
References
Ref 529353	J Med Chem. 2008 Mar 27;51(6):1706-18. Epub 2008 Mar 5.Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.
Ref 529353	J Med Chem. 2008 Mar 27;51(6):1706-18. Epub 2008 Mar 5.Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.
Ref 529817	Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. Epub 2008 Nov 8.Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.
Ref 534507	J Med Chem. 1997 Nov 7;40(23):3773-80.Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity.

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