Drug Information

Drug General Information
Drug ID
D02GJZ
Former ID
DNAP001686
Drug Name
Ioflupane i-123
Synonyms
Datscan (TN)
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Approved [531783]
Company
GE Healthcare
Structure
Download
2D MOL

3D MOL
Formula
C18H23FINO2
Canonical SMILES
COC(=O)C1C2CCC(N2CCCF)CC1C3=CC=C(C=C3)I
InChI
1S/C18H23FINO2/c1-23-18(22)17-15(12-3-5-13(20)6-4-12)11-14-7-8-16(17)21(14)10-2-9-19/h3-6,14-17H,2,7-11H2,1H3/t14?,15-,16?,17+/m1/s1/i20-4
InChIKey
HXWLAJVUJSVENX-PUMJCJFRSA-N
CAS Number
CAS 155798-07-5
PubChem Compound ID
56928188
PubChem Substance ID
135626735, 160676234
ChEBI ID
ChEBI:68855
SuperDrug ATC ID
V09AB03
Target and Pathway
Target(s) Sodium-dependent dopamine transporter Target Info Modulator [551871]
KEGG Pathway Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 5317832011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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