Drug General Information
Drug ID	D02HCU
Former ID	DIB006289
Drug Name	WEB-2347
Drug Type	Small molecular drug
Indication	Allergy [ICD9: 995.3; ICD10:T78.4]		Terminated	[544959]
Company	Boehringer Ingelheim Corp
Structure		Download 2D MOL 3D MOL
Formula	C25H28ClN5OS
Canonical SMILES	c12c(n3c(nnc3)CN=C2c2c(Cl)cccc2)sc2c1CC(C(=O)N(CCC)CCC)<br />C2
CAS Number	CAS 114800-19-0
PubChem Compound ID	3081067
Target and Pathway
Target(s)	Platelet-activating factor receptor	Target Info	Modulator	[529756]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Staphylococcus aureus infection
NetPath Pathway	IL5 Signaling Pathway
	Leptin Signaling Pathway
Reactome	Class A/1 (Rhodopsin-like receptors)
	G alpha (q) signalling events
	Interferon gamma signaling
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	Interferon gamma signaling
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544959	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001720)
Ref 529756	WEB 2347: pharmacology of a new very potent and long acting hetrazepinoic PAF-antagonist and its action in repeatedly sensitized guinea-pigs. J Lipid Mediat. 1991 Jul-Aug;4(1):39-44.

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