Drug General Information
Drug ID	D02HWP
Former ID	DNC011357
Drug Name	CHLOROXINE
Drug Type	Small molecular drug
Indication	Erythema [ICD9: 695; ICD10:L51-L54]		Approved	[551871]
Structure		Download 2D MOL 3D MOL
Formula	C9H5Cl2NO
Canonical SMILES	C1=CC2=C(C(=C(C=C2Cl)Cl)O)N=C1
InChI	1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
InChIKey	WDFKMLRRRCGAKS-UHFFFAOYSA-N
CAS Number	CAS 773-76-2
PubChem Compound ID	2722
Target and Pathway
Target(s)	Kappa-type opioid receptor	Target Info	Inhibitor	[531262]
KEGG Pathway	Neuroactive ligand-receptor interaction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Opioid prodynorphin pathway
Reactome	Peptide ligand-binding receptors
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 531262	Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).

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