Drug Information

Drug General Information
Drug ID
D02JCM
Former ID
DIB020463
Drug Name
N(6)-cyclohexyladenosine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467565]
Structure
Download
2D MOL
Formula
C16H23N5O4
InChI
InChI=1S/C16H23N5O4/c22-6-10-12(23)13(24)16(25-10)21-8-19-11-14(17-7-18-15(11)21)20-9-4-2-1-3-5-9/h7-10,12-13,16,22-24H,1-6H2,(H,17,18,20)/t10-,12-,13-,16-/m1/s1
InChIKey
SZBULDQSDUXAPJ-XNIJJKJLSA-N
PubChem Compound ID
9841284
PubChem Substance ID
14802819, 17404894, 24139429, 26753545, 44939362, 47574445, 47574446, 47574447, 47721688, 47796119, 47870803, 48095612, 50106092, 50106093, 53777437, 79854249, 90341655, 92303773, 103228861, 103922563, 103959360, 121361167, 124749627, 129309435, 134224717, 135650675, 140033717, 143178625, 162090737, 163410110, 163564285, 163848500, 172855788, 189053184, 223558168, 224442731, 226512189, 249846057, 252035498, 252212978, 252484514
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Agonist [534039]
Adenosine A2b receptor Target Info Agonist [533531]
Adenosine A3 receptor Target Info Agonist [534114]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addictionhsa04015:Rap1 signaling pathway
Calcium signaling pathway
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TCR Signaling Pathway
RANKL Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
GPCRs, Other
References
Ref 467565(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 423).
Ref 533531Adenosine receptor activation in human fibroblasts: nucleoside agonists and antagonists. Can J Physiol Pharmacol. 1980 Jun;58(6):673-91.
Ref 534039Structure-activity relationships for 2-substituted adenosines at A1 and A2 adenosine receptors. Pharmacology. 1993;46(2):91-100.
Ref 534114Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors. J Immunol. 1996 May 1;156(9):3435-42.

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