Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02JUT
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| Former ID |
DNC000149
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| Drug Name |
Acivicin
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Discontinued in Phase 3 | [544734] | ||
| Structure |
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Download2D MOL |
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| Formula |
C5H7ClN2O3
|
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| Canonical SMILES |
C1C(ON=C1Cl)C(C(=O)O)N
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| InChI |
1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)/t2-,4-/m0/s1
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| InChIKey |
QAWIHIJWNYOLBE-OKKQSCSOSA-N
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| CAS Number |
CAS 42228-92-2
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| PubChem Compound ID | |||||
| PubChem Substance ID |
301209, 604683, 8137178, 8149785, 8874383, 11335847, 11361086, 11363237, 11365799, 11368361, 11372873, 11374503, 11376523, 11405636, 11446677, 11462058, 11491672, 11492717, 11494157, 12012692, 15171287, 17396913, 24769896, 26612246, 26679404, 34834567, 47440265, 47959748, 47959749, 50122781, 50927642, 53787108, 57401220, 85147462, 99301760, 104247289, 104495125, 124633291, 131314443, 134339664, 135000593, 137241165, 144205098, 162219966, 163132478, 163725839, 164784296, 179038041, 184573969, 198977092
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| Target and Pathway | |||||
| Target(s) | Carbamoyl-phosphate synthase II | Target Info | Inhibitor | [537677] | |
| CTP synthase | Target Info | Inhibitor | [535177], [537820] | ||
| KEGG Pathway | Pyrimidine metabolism | ||||
| Metabolic pathways | |||||
| PANTHER Pathway | De novo pyrimidine ribonucleotides biosythesis | ||||
| PathWhiz Pathway | Pyrimidine Metabolism | ||||
| WikiPathways | Metabolism of nucleotides | ||||
| References | |||||
| Ref 535177 | Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6412-6. Epub 2001 May 15. | ||||
| Ref 537677 | Acivicin: a highly active potential chemotherapeutic agent against visceral leishmaniasis. Biochem Biophys Res Commun. 1990 Jul 31;170(2):426-32. | ||||
| Ref 537820 | Synergistic effects with inhibitors of de novo pyrimidine synthesis, acivicin, and N-(phosphonacetyl)-L-aspartic acid. Cancer Res. 1981 Sep;41(9 Pt 1):3419-23. | ||||
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