Drug General Information
Drug ID
D02KIU
Former ID
DAP000855
Drug Name
Etonogestrel
Synonyms
Etonogestrelum; Implanon; Implanon (TN); NuvaRing (TN); Etonogestrel (USAN/INN); (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-11-methylidene-2,6,7,8,9,10,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one; 17alpha-ethynyl-17beta-hydroxy-11-methylidene-18a-homo-estr-4-en-3-one; 3-Ketodesogestrel; 3-Oxodesogestrel
Drug Type
Small molecular drug
Indication Female contraception [ICD10:Z30] Approved [536361], [542580]
Therapeutic Class
Contraceptive Agents
Structure
Download
2D MOL

3D MOL

Formula
C22H28O2
InChI
InChI=1S/C22H28O2/c1-4-21-13-14(3)20-17-9-7-16(23)12-15(17)6-8-18(20)19(21)10-11-22(21,24)5-2/h2,12,17-20,24H,3-4,6-11,13H2,1H3/t17-,18-,19-,20+,21-,22-/m0/s1
InChIKey
GCKFUYQCUCGESZ-BPIQYHPVSA-N
CAS Number
CAS 54048-10-1
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:50777
SuperDrug ATC ID
G03AC08
SuperDrug CAS ID
cas=054048101
Target and Pathway
Target(s) Progesterone receptor Target Info Binder [535188], [537309]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturation
Pathway Interaction Database Cellular roles of Anthrax toxin
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear Receptors
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 542580(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7590).
Ref 535188Endometrial effects of etonogestrel (Implanon) contraceptive implant. Curr Opin Obstet Gynecol. 2001 Jun;13(3):335-41.
Ref 537309Pharmacological profile of progestins. Maturitas. 2008 Sep-Oct;61(1-2):151-7.

If you find any error in data or bug in web service, please kindly report it to Dr. Wang and Dr. Li.