Drug Information

Drug General Information
Drug ID
D02KWT
Former ID
DNC007005
Drug Name
BISINDOLYLMALEIMIDE IX
Drug Type
Small molecular drug
Indication Discovery agent Investigative [525872]
Structure
Download
2D MOL
Formula
C25H23N5O2S
Canonical SMILES
CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)<br />CCCSC(=N)N
InChI
1S/C25H23N5O2S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32)
InChIKey
DSXXEELGXBCYNQ-UHFFFAOYSA-N
PubChem Compound ID
5083
Target and Pathway
Target(s) Glycogen synthase kinase-3 beta Target Info Inhibitor [525872]
NAD-dependent deacetylase sirtuin-1 Target Info Inhibitor [528556]
Mitogen-activated protein kinase 8 Target Info Inhibitor [525872]
Protein kinase C, alpha type Target Info Inhibitor [525872]
Mitogen-activated protein kinase 11 Target Info Inhibitor [525872]
Mitogen-activated protein kinase 14 Target Info Inhibitor [525872]
RAC serine/threonine-protein kinase Target Info Inhibitor [525872]
Lck tyrosine kinase Target Info Inhibitor [525872]
Mitogen-activated protein kinase 1 Target Info Inhibitor [525872]
Ribosomal protein S6 kinase Target Info Inhibitor [525872]
Rho-associated protein kinase 1 Target Info Inhibitor [525872]
MAP kinase p38 Target Info Inhibitor [525872]
KEGG Pathway ErbB signaling pathway
Chemokine signaling pathway
Cell cycle
PI3K-Akt signaling pathway
Wnt signaling pathway
Hedgehog signaling pathway
Axon guidance
Hippo signaling pathway
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
T cell receptor signaling pathway
B cell receptor signaling pathway
Neurotrophin signaling pathway
Dopaminergic synapse
Insulin signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer's disease
Hepatitis C
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Colorectal cancer
Endometrial cancer
Prostate cancer
Basal cell carcinomahsa04068:FoxO signaling pathway
AMPK signaling pathway
Glucagon signaling pathway
Amphetamine addiction
MicroRNAs in cancerhsa04010:MAPK signaling pathway
Ras signaling pathway
cAMP signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Protein processing in endoplasmic reticulum
Osteoclast differentiation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Retrograde endocannabinoid signaling
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Adipocytokine signaling pathway
Type II diabetes mellitus
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Salmonella infection
Pertussis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis B
Herpes simplex infection
Pancreatic cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
VEGF signaling pathway
Tight junction
Gap junction
Natural killer cell mediated cytotoxicity
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Long-term depression
Insulin secretion
Thyroid hormone synthesis
Oxytocin signaling pathway
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Morphine addiction
Vibrio cholerae infection
Pathogenic Escherichia coli infection
African trypanosomiasis
Amoebiasis
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Platelet activation
Amyotrophic lateral sclerosis (ALS)
Leishmaniasis
Proteoglycans in cancerhsa04010:MAPK signaling pathway
cGMP-PKG signaling pathway
Apoptosis
Jak-STAT signaling pathway
Estrogen signaling pathway
Regulation of lipolysis in adipocytes
Carbohydrate digestion and absorption
Renal cell carcinoma
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04064:NF-kappa B signaling pathway
Primary immunodeficiencyhsa04010:MAPK signaling pathway
Oocyte meiosis
Dorso-ventral axis formation
TGF-beta signaling pathway
Adherens junction
Regulation of actin cytoskeleton
Prion diseases
Alcoholism
Viral carcinogenesis
Thyroid cancer
Bladder cancer
Choline metabolism in cancerhsa04012:ErbB signaling pathway
Choline metabolism in cancerhsa04022:cGMP-PKG signaling pathway
NetPath Pathway IL5 Signaling Pathway
TNFalpha Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_17:IL5 Signaling Pathway
FSH Signaling Pathway
TCR Signaling PathwayNetPath_23:TSH Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathway
Angiogenesis
Cadherin signaling pathway
Hedgehog signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Insulin/IGF pathway-protein kinase B signaling cascade
Interleukin signaling pathway
PDGF signaling pathway
PI3 kinase pathway
Wnt signaling pathway
Ras Pathway
CCKR signaling map STP00059:p53 pathwayP00003:Alzheimer disease-amyloid secretase pathway
Apoptosis signaling pathway
B cell activation
FAS signaling pathway
Integrin signalling pathway
Interferon-gamma signaling pathway
Oxidative stress response
Parkinson disease
TGF-beta signaling pathway
T cell activation
Toll receptor signaling pathway
CCKR signaling map STP00002:Alpha adrenergic receptor signaling pathway
Alzheimer disease-amyloid secretase pathway
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
VEGF signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathway
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
p53 pathway feedback loops 2
p38 MAPK pathwayP00003:Alzheimer disease-amyloid secretase pathway
p38 MAPK pathway
CCKR signaling map STP00005:Angiogenesis
Huntington disease
Hypoxia response via HIF activation
Inflammation mediated by chemokine and cytokine signaling pathway
p53 pathway
p53 pathway by glucose deprivation
CCKR signaling map STP00049:Parkinson disease
T cell activationP00003:Alzheimer disease-amyloid secretase pathway
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
CCKR signaling map STP00032:Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
CCKR signaling map STP00016:Cytoskeletal regulation by Rho GTPase
Pathway Interaction Database LPA receptor mediated events
Degradation of beta catenin
Reelin signaling pathway
Presenilin action in Notch and Wnt signaling
Integrin-linked kinase signaling
CDC42 signaling events
LKB1 signaling events
Canonical Wnt signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Glucocorticoid receptor regulatory network
C-MYC pathway
Regulation of Androgen receptor activity
BMP receptor signaling
Hedgehog signaling events mediated by Gli proteins
Signaling events mediated by Stem cell factor receptor (c-Kit)
Validated transcriptional targets of deltaNp63 isoforms
Aurora A signaling
Insulin-mediated glucose transport
Class I PI3K signaling events mediated by Akt
p53 pathway
Trk receptor signaling mediated by PI3K and PLC-gammap73pathway:p73 transcription factor network
Signaling events mediated by HDAC Class III
E2F transcription factor network
HIF-2-alpha transcription factor network
Signaling events mediated by HDAC Class I
FoxO family signaling
Regulation of retinoblastoma proteinfcer1pathway:Fc-epsilon receptor I signaling in mast cells
Endothelins
BCR signaling pathway
RhoA signaling pathway
Noncanonical Wnt signaling pathway
CD40/CD40L signaling
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Osteopontin-mediated events
TRAIL signaling pathway
Signaling events regulated by Ret tyrosine kinase
Angiopoietin receptor Tie2-mediated signaling
FAS (CD95) signaling pathway
IL1-mediated signaling events
IL2-mediated signaling events
Rapid glucocorticoid signaling
Ceramide signaling pathway
p75(NTR)-mediated signaling
ErbB1 downstream signaling
ATF-2 transcription factor network
ErbB2/ErbB3 signaling events
PDGFR-beta signaling pathway
JNK signaling in the CD4+ TCR pathway
Nephrin/Neph1 signaling in the kidney podocyte
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Retinoic acid receptors-mediated signaling
EPO signaling pathway
Syndecan-2-mediated signaling events
Ephrin B reverse signaling
N-cadherin signaling events
S1P2 pathway
Downstream signaling in na&#xef
RAC1 signaling pathway
Signaling events mediated by focal adhesion kinase
Glypican 3 network
IL12 signaling mediated by STAT4endothelinpathway:Endothelins
TCR signaling in na&#xef
Canonical NF-kappaB pathway
TCR signaling in na&#xef
Thromboxane A2 receptor signaling
mTOR signaling pathway
Ras signaling in the CD4+ TCR pathway
Syndecan-4-mediated signaling events
IL8- and CXCR2-mediated signaling events
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2
PAR1-mediated thrombin signaling events
a6b1 and a6b4 Integrin signaling
IL8- and CXCR1-mediated signaling events
Regulation of Ras family activation
p73 transcription factor network
p38 MAPK signaling pathway
Plasma membrane estrogen receptor signaling
Regulation of p38-alpha and p38-beta
IL6-mediated signaling events
p38 signaling mediated by MAPKAP kinases
CXCR3-mediated signaling events
Signaling mediated by p38-alpha and p38-beta
VEGFR3 signaling in lymphatic endothelium
Regulation of retinoblastoma proteinendothelinpathway:Endothelins
p73 transcription factor network
Atypical NF-kappaB pathway
IL4-mediated signaling events
IL12-mediated signaling events
Trk receptor signaling mediated by the MAPK pathway
FGF signaling pathway
Regulation of retinoblastoma proteinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Fc-epsilon receptor I signaling in mast cells
Insulin Pathway
Signaling events mediated by PTP1B
S1P3 pathway
Coregulation of Androgen receptor activity
Regulation of Telomerase
FOXA2 and FOXA3 transcription factor networks
CXCR4-mediated signaling events
IGF1 pathway
IL2 signaling events mediated by PI3K
E-cadherin signaling in the nascent adherens junction
amb2 Integrin signaling
Integrins in angiogenesis
IFN-gamma pathway
E-cadherin signaling in keratinocytes
Signaling events mediated by the Hedgehog family
Nongenotropic Androgen signaling
Caspase Cascade in Apoptosis
HIF-1-alpha transcription factor network
Trk receptor signaling mediated by PI3K and PLC-gamma
FGF signaling pathwaynfkappabatypicalpathway:Atypical NF-kappaB pathway
Glypican 1 network
SHP2 signaling
Class I PI3K signaling events
EPHA forward signaling
IL2 signaling events mediated by STAT5
Alpha-synuclein signalingfcer1pathway:Fc-epsilon receptor I signaling in mast cells
Signaling events mediated by PRL
ErbB4 signaling events
GMCSF-mediated signaling events
EPHB forward signaling
S1P4 pathway
S1P1 pathway
Netrin-mediated signaling events
Arf6 downstream pathway
Class IB PI3K non-lipid kinase events
EGF receptor (ErbB1) signaling pathway
ALK1 signaling events
Neurotrophic factor-mediated Trk receptor signaling
Syndecan-1-mediated signaling events
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Cellular roles of Anthrax toxin
Alpha-synuclein signaling
Signaling events mediated by focal adhesion kinaseinsulin_pathway:Insulin Pathway
RXR and RAR heterodimerization with other nuclear receptor
TGF-beta receptor signalingprlsignalingeventspathway:Signaling events mediated by PRL
PAR4-mediated thrombin signaling events
Stabilization and expansion of the E-cadherin adherens junction
N-cadherin signaling eventsrhoa_pathway:RhoA signaling pathway
Signaling mediated by p38-gamma and p38-delta
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Fc Epsilon Receptor I Signaling in Mast CellsPW000453:Fc Epsilon Receptor I Signaling in Mast Cells
Activation of PKC through G protein coupled receptorPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000453:Fc Epsilon Receptor I Signaling in Mast CellsPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Fc Epsilon Receptor I Signaling in Mast Cells
Insulin Signalling
Leucine Stimulation on Insulin SignalingPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Insulin SignallingPW000659:Leucine Stimulation on Insulin Signaling
Reactome Degradation of beta-catenin by the destruction complex
AKT phosphorylates targets in the cytosol
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
Degradation of GLI2 by the proteasome
Constitutive Signaling by AKT1 E17K in CancerR-HSA-1368082:RORA activates gene expression
Circadian ClockR-HSA-193648:NRAGE signals death through JNK
NRIF signals cell death from the nucleus
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
DSCAM interactions
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksR-HSA-111933:Calmodulin induced events
Disinhibition of SNARE formation
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Inactivation, recovery and regulation of the phototransduction cascade
Syndecan interactions
Acetylcholine regulates insulin secretion
Ca2+ pathway
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
Depolymerisation of the Nuclear Lamina
HuR (ELAVL1) binds and stabilizes mRNA
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
Response to elevated platelet cytosolic Ca2+R-HSA-168638:NOD1/2 Signaling Pathway
p38MAPK events
ERK/MAPK targets
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
CDO in myogenesis
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
KSRP (KHSRP) binds and destabilizes mRNAR-HSA-168638:NOD1/2 Signaling Pathway
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
KSRP (KHSRP) binds and destabilizes mRNAR-HSA-111447:Activation of BAD and translocation to mitochondria
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Translocation of GLUT4 to the plasma membrane
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
eNOS activation
AKT-mediated inactivation of FOXO1A
Integrin alphaIIb beta3 signaling
Deactivation of the beta-catenin transactivating complex
CD28 dependent PI3K/Akt signaling
CTLA4 inhibitory signaling
G beta:gamma signalling through PI3Kgamma
KSRP (KHSRP) binds and destabilizes mRNA
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in CancerR-HSA-114604:GPVI-mediated activation cascade
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
CD28 co-stimulation
CD28 dependent Vav1 pathway
PD-1 signaling
Interleukin-2 signalingR-HSA-112409:RAF-independent MAPK1/3 activation
MAPK1 (ERK2) activation
Golgi Cisternae Pericentriolar Stack Reorganization
Regulation of actin dynamics for phagocytic cup formation
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
NCAM signaling for neurite out-growth
Recycling pathway of L1
CREB phosphorylation through the activation of Ras
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Growth hormone receptor signalingR-HSA-166208:mTORC1-mediated signallingR-HSA-111465:Apoptotic cleavage of cellular proteins
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
RHO GTPases Activate ROCKsR-HSA-168638:NOD1/2 Signaling Pathway
WikiPathways DNA Damage Response (only ATM dependent)
Senescence and Autophagy in Cancer
Notch Signaling Pathway
Glycogen Metabolism
Insulin Signaling
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
IL-6 signaling pathway
Wnt Signaling Pathway Netpath
Copper homeostasis
Focal Adhesion
Hair Follicle Development: Induction (Part 1 of 3)
Cardiac Hypertrophic Response
Degradation of beta-catenin by the destruction complex
T-Cell Receptor and Co-stimulatory Signaling
Cardiac Progenitor Differentiation
BDNF signaling pathway
Corticotropin-releasing hormone
B Cell Receptor Signaling Pathway
IL17 signaling pathway
Neural Crest Differentiation
Alzheimers Disease
IL-7 Signaling Pathway
Regulation of Microtubule Cytoskeleton
TWEAK Signaling Pathway
Leptin signaling pathway
Semaphorin interactions
Cell Cycle
MicroRNAs in cardiomyocyte hypertrophy
Androgen receptor signaling pathway
IL-5 Signaling PathwayWP2377:Integrated Pancreatic Cancer Pathway
SREBF and miR33 in cholesterol and lipid homeostasis
Integrated Breast Cancer Pathway
SREBP signalling
Androgen receptor signaling pathwayWP75:Toll-like receptor signaling pathway
TCR Signaling Pathway
ErbB Signaling Pathway
EGF/EGFR Signaling Pathway
MAPK Signaling Pathway
TGF beta Signaling Pathway
FAS pathway and Stress induction of HSP regulation
Signaling of Hepatocyte Growth Factor Receptor
Kit receptor signaling pathway
Transcriptional activation by NRF2
NLR Proteins
IL-3 Signaling Pathway
Nanoparticle-mediated activation of receptor signaling
Structural Pathway of Interleukin 1 (IL-1)
EBV LMP1 signaling
JAK/STAT
PDGF Pathway
Nanoparticle triggered regulated necrosis
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
AGE/RAGE pathway
TNF alpha Signaling Pathway
Prostate Cancer
TSLP Signaling Pathway
RANKL/RANK Signaling Pathway
Signalling by NGF
IL-1 signaling pathway
Intrinsic Pathway for Apoptosis
DSCAM interactions
Apoptosis Modulation and Signaling
Type II diabetes mellitus
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathway
Osteoclast SignalingWP673:ErbB Signaling Pathway
Calcium Regulation in the Cardiac Cell
G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Human Complement System
Syndecan interactions
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
Signaling by SCF-KIT
DAG and IP3 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Alpha 6 Beta 4 signaling pathway
Spinal Cord Injury
Pathogenic Escherichia coli infection
Signaling Pathways in Glioblastoma
Endothelin Pathways
FSH signaling pathway
miRs in Muscle Cell Differentiation
Opioid Signalling
Response to elevated platelet cytosolic Ca2+
Integration of energy metabolism
TOR SignalingWP75:Toll-like receptor signaling pathway
IL-4 Signaling Pathway
MAP kinase activation in TLR cascade
Parkinsons Disease Pathway
NGF signalling via TRKA from the plasma membrane
Myogenesis
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
Monoamine Transport
Serotonin HTR1 Group and FOS Pathway
Interferon type I signaling pathways
MAPK Cascade
Oxidative Stress
p38 MAPK Signaling Pathway
Amyotrophic lateral sclerosis (ALS)
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
Signal amplification
Platelet homeostasis
Angiogenesis
EPO Receptor Signaling
IL-2 Signaling Pathway
Endochondral Ossification
Extracellular vesicle-mediated signaling in recipient cells
Apoptosis-related network due to altered Notch3 in ovarian cancer
Translocation of GLUT4 to the Plasma Membrane
PIP3 activates AKT signaling
Signal Transduction of S1P Receptor
Primary Focal Segmental Glomerulosclerosis FSGS
Apoptosis
Interleukin-11 Signaling Pathway
TSH signaling pathway
Integrated Cancer pathway
Metabolism of nitric oxide
Integrin-mediated Cell Adhesion
TFs Regulate miRNAs related to cardiac hypertrophy
TOR Signaling
AMPK Signaling
IL-5 Signaling PathwayWP61:Notch Signaling Pathway
Inflammatory Response Pathway
DAP12 interactions
Host Interactions of HIV factors
TCR signaling
Costimulation by the CD28 familyWP75:Toll-like receptor signaling pathway
Serotonin Receptor 4/6/7 and NR3C Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Vitamin A and Carotenoid Metabolism
Hypothetical Network for Drug Addiction
Regulation of Actin Cytoskeleton
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
Bladder Cancer
Fc epsilon receptor (FCERI) signaling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
RAF/MAP kinase cascade
Genes and (Common) Pathways Underlying Drug Addiction
Nifedipine Activity
Aryl Hydrocarbon Receptor
IL-9 Signaling Pathway
Thrombin signalling through proteinase activated receptors (PARs)
Signaling by FGFR
L1CAM interactions
Advanced glycosylation endproduct receptor signaling
Heart Development
Osteopontin Signaling
IL-5 Signaling PathwayWP673:ErbB Signaling Pathway
G13 Signaling Pathway
Cytoplasmic Ribosomal Proteins
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Signaling by Insulin receptor
IL-5 Signaling PathwayWP524:G13 Signaling Pathway
GPCR downstream signaling
Apoptotic execution phase
References
Ref 525872Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Ref 525872Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Ref 528556J Med Chem. 2006 Dec 14;49(25):7307-16.Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition.

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