Drug Information

Drug General Information
Drug ID
D02NGR
Former ID
DNC004161
Drug Name
MK-499
Drug Type
Small molecular drug
Indication Cardiac arrhythmias [ICD9: 427; ICD10:I47-I49] Discontinued in Phase 2 [539684], [545349]
Structure
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2D MOL

3D MOL
Formula
C25H29N3O4S
InChI
InChI=1S/C25H29N3O4S/c1-33(30,31)27-20-5-7-24-22(14-20)23(29)15-25(32-24)8-10-28(11-9-25)21-6-4-18-12-17(16-26)2-3-19(18)13-21/h2-3,5,7,12,14,21,23,27,29H,4,6,8-11,13,15H2,1H3/t21-,23-/m1/s1
InChIKey
NIYGLRKUBPNXQS-FYYLOGMGSA-N
PubChem Compound ID
9934294
PubChem Substance ID
14907354, 15155281, 24208880, 53786061, 53801034, 77708428, 96099847, 103630593, 134348025, 230608867, 247541800
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily H member 2 Target Info Inhibitor [526620]
PathWhiz Pathway Muscle/Heart Contraction
Reactome Voltage gated Potassium channels
WikiPathways SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Potassium Channels
References
Ref 539684(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2607).
Ref 545349Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002963)
Ref 526620Bioorg Med Chem Lett. 2003 May 19;13(10):1829-35.Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches.

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