Drug Information

Drug General Information
Drug ID
D02OLS
Former ID
DIB014577
Drug Name
PPAR delta agonists
Synonyms
PPAR delta agonists (dyslipidemia/diabetes/obesity/atherosclerosis); PPAR delta agonists (dyslipidemia/diabetes/obesity/atherosclerosis), Astrazeneca
Indication Atherosclerosis [ICD9: 414.0, 440; ICD10:I70] Investigative [552085]
Company
AstraZeneca plc
Structure
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2D MOL

3D MOL
Canonical SMILES
c1c(ccc(c1Cl)NC(=O)[C@H](N1Cc2c(CCC1)ccc(c2)OCC(=O)O)CC<br />)Cl
Target and Pathway
Target(s) Peroxisomeproliferator activated receptor delta Target Info Agonist [543890]
KEGG Pathway PPAR signaling pathway
Wnt signaling pathway
Pathways in cancer
Acute myeloid leukemia
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Wnt signaling pathway
Pathway Interaction Database Presenilin action in Notch and Wnt signaling
RXR and RAR heterodimerization with other nuclear receptor
Reactome Import of palmitoyl-CoA into the mitochondrial matrix
Regulation of pyruvate dehydrogenase (PDH) complex
Nuclear Receptor transcription pathway
WikiPathways Wnt Signaling Pathway and Pluripotency
Nuclear Receptors in Lipid Metabolism and Toxicity
NRF2 pathway
Nuclear Receptors Meta-Pathway
Vitamin D Receptor Pathway
Ectoderm Differentiation
Adipogenesis
Nuclear Receptors
References
Ref 552085Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPAR? agonists. Bioorg Med Chem Lett. 2011 Jan 1;21(1):492-6
Ref 543890(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 594).

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