Drug General Information
Drug ID	D02OZB
Former ID	DNC011798
Drug Name	2-Piperazin-1-yl-phenol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533476]
Structure		Download 2D MOL 3D MOL
Formula	C10H14N2O
Canonical SMILES	C1CN(CCN1)C2=CC=CC=C2O
InChI	1S/C10H14N2O/c13-10-4-2-1-3-9(10)12-7-5-11-6-8-12/h1-4,11,13H,5-8H2
InChIKey	UORNTHBBLYBAJJ-UHFFFAOYSA-N
PubChem Compound ID	70530
Target and Pathway
Target(s)	5-hydroxytryptamine 1D receptor	Target Info	Inhibitor	[533476]
	5-hydroxytryptamine 2A receptor	Target Info	Inhibitor	[533476]
	5-hydroxytryptamine 1A receptor	Target Info	Inhibitor	[533476]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapsehsa04020:Calcium signaling pathway
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR downstream signaling
	GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
References
Ref 533476	J Med Chem. 1986 May;29(5):630-4.Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents.
Ref 533476	J Med Chem. 1986 May;29(5):630-4.Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents.

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