Drug Information

Drug General Information
Drug ID
D02PHE
Former ID
DCL000489
Drug Name
AZD9668
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Discontinued in Phase 2 [541611], [548573]
Company
AstraZeneca
Structure
Download
2D MOL

3D MOL
Formula
C25H22F3N5O4S
InChI
InChI=1S/C25H22F3N5O4S/c1-15-20(22-9-10-31-32(22)2)12-21(23(34)30-13-17-7-8-19(14-29-17)38(3,36)37)24(35)33(15)18-6-4-5-16(11-18)25(26,27)28/h4-12,14H,13H2,1-3H3,(H,30,34)
InChIKey
QNQZWEGMKJBHEM-UHFFFAOYSA-N
PubChem Compound ID
46861623
PubChem Substance ID
104171469, 141045380, 172819740, 178103090, 210275277, 210280918, 224420957, 226868273, 249073543, 251910735, 252214943, 252451609
SuperDrug ATC ID
J01DD06
SuperDrug CAS ID
cas=064952972
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [550288]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 541611(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6476).
Ref 548573Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026715)
Ref 550288Clinical pipeline report, company report or official report of AstraZeneca (2009).

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