Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02PMO
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| Former ID |
DAP000648
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| Drug Name |
Topotecan
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| Synonyms |
Hycamptamine; Hycamptin; Hycamtamine; Hycamtin; Topotecane; Topotecanum; Topotecan lactone; SKF 104864; Hycamtin (TN); SKF-S 104864; TOPOTECAN, HYCAMTIN; Topotecan (BAN); Topotecan [INN:BAN]; Topotecane [INN-French]; Topotecanum [INN-Latin]; SKF-104864-A; SK&F-104864-A; Topotecan Monohydrochloride, (S)-Isomer; (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione; (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 9-Dimethylaminomethyl-10-hydroxycamptothecin
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Anticancer Agents
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| Company |
GlaxoSmithKline
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| Structure |
|
Download2D MOL |
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| Formula |
C23H23N3O5
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| InChI |
InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1
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| InChIKey |
UCFGDBYHRUNTLO-QHCPKHFHSA-N
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| CAS Number |
CAS 119413-54-6
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| PubChem Compound ID | |||||
| PubChem Substance ID |
13340, 581639, 606579, 7890901, 7980817, 8187013, 11409161, 11459078, 11461196, 14807035, 14904851, 24769902, 43118056, 46505204, 47348955, 47499101, 47572929, 48242924, 50028360, 50123362, 53790588, 56311903, 57314070, 78527173, 92309036, 92710943, 96025302, 103170619, 103922004, 103942242, 104321416, 117586312, 124878927, 124878928, 126631363, 126682466, 129347572, 134337938, 135026276, 135610141, 136342520, 136376449, 137007926, 137275799, 142090317, 144220376, 152106211, 152198470, 160660968, 160964365
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| SuperDrug ATC ID |
L01XX17
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| SuperDrug CAS ID |
cas=123948878
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| Drug Resistance Mutation (DRM) | |||||
| DRM | DRM Info | ||||
| Target and Pathway | |||||
| Target(s) | DNA topoisomerase I | Target Info | Modulator | [556264] | |
| WikiPathways | Integrated Pancreatic Cancer Pathway | ||||
| References | |||||
| Ref 536361 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. | ||||
| Ref 542109 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7101). | ||||
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