Drug Information

Drug General Information
Drug ID
D02POH
Former ID
DIB015744
Drug Name
TA-7906
Synonyms
T-2585; PDE4 inhibitor (skin disease), Maruho; PDE4 inhibitors (inflammation), Tanabe Seiyaku; T-2585.HCl
Indication Atopic dermatitis [ICD9: 691.8, 692.9; ICD10:L00-L99] Phase 2 [548322]
Company
Tanabe Seiyaku Co Ltd
Structure
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2D MOL

3D MOL
Canonical SMILES
n1(nc(c2c(c1=O)cccc2)c1nccs1)c1cc(c2c3c(cc(c(c3)OCC)OCC<br />)cc(n2)CO)ccn1
CAS Number
CAS 186461-26-7
Target and Pathway
Target(s) Type IV phosphodiesterase Target Info Inhibitor [526360]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [526360]
CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [526360]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
TSH signaling pathwayWP35:G Protein Signaling Pathways
Nuclear Receptors Meta-Pathway
Opioid SignallingWP35:G Protein Signaling Pathways
References
Ref 548322Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024588)
Ref 526360Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors. Clin Exp Immunol. 2002 Jun;128(3):460-6.

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