TTD | Drug: D02QCD

Drug General Information
Drug ID	D02QCD
Former ID	DNC013272
Drug Name	DEXMETHYLPHENIDATE HYDROCHLORIDE
Drug Type	Small molecular drug
Indication	Attention deficit hyperactivity disorder [ICD9: 314; ICD10:F90]		Approved	[551871]
Structure		Download 2D MOL 3D MOL
Formula	C14H20ClNO2
Canonical SMILES	COC(=O)C(C1CCCCN1)C2=CC=CC=C2.Cl
InChI	1S/C14H19NO2.ClH/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12;/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3;1H/t12-,13-;/m1./s1
InChIKey	JUMYIBMBTDDLNG-OJERSXHUSA-N
PubChem Compound ID	154100
SuperDrug ATC ID	N06BA11
Target and Pathway
Target(s)	Sodium-dependent dopamine transporter	Target Info	Inhibitor	[528826]
KEGG Pathway	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Amphetamine addiction
	Alcoholism
PANTHER Pathway	Adrenaline and noradrenaline biosynthesis
	Parkinson disease
	Dopamine receptor mediated signaling pathway
Pathway Interaction Database	Alpha-synuclein signaling
Reactome	Na+/Cl- dependent neurotransmitter transporters
WikiPathways	Monoamine Transport
	NRF2 pathway
	Dopaminergic Neurogenesis
	Parkinsons Disease Pathway
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 528826	J Med Chem. 2007 May 31;50(11):2718-31. Epub 2007 May 10.Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate.

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Drug Information