Drug General Information
Drug ID	D02RPK
Drug Name	Z 360
Synonyms	Z-360
Drug Type	Small molecular drug
Indication	Unspecified		Phase 2	[1560000], [1560439]
Therapeutic Class	Anticancer Agents
Structure		Download 2D MOL 3D MOL
Formula	C29H36N4O5
PubChem Compound ID	9872609
Target and Pathway
Target(s)	Gastrin/cholecystokinin type B receptor	Target Info	Modulator
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gastric acid secretion
PANTHER Pathway	CCKR signaling map ST
PathWhiz Pathway	Gastric Acid Production
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
	Gastrin-CREB signalling pathway via PKC and MAPK
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Secretion of Hydrochloric Acid in Parietal Cells
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 1560000	Z-360, a novel therapeutic agent for pancreatic cancer, prevents up-regulation of ephrin B1 gene expression and phosphorylation of NR2B via suppression of interleukin-1 production in a cancer-induced pain model in mice.Mol Pain.2010 Oct 28;6:72.
Ref 1560439	Z-360, a novel cholecystokinin-2/gastrin receptor antagonist, inhibits gemcitabine-induced expression of the vascular endothelial growth factor gene in human pancreatic cancer cells.

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