Drug Information

Drug General Information
Drug ID
D02RQP
Former ID
DIB018981
Drug Name
bisphenol A
Synonyms
BPA
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526643]
Structure
Download
2D MOL
Formula
C15H16O2
InChI
InChI=1S/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3
InChIKey
IISBACLAFKSPIT-UHFFFAOYSA-N
PubChem Compound ID
6623
PubChem Substance ID
68531, 81140, 586242, 893061, 3135927, 4950518, 7978799, 8154266, 10536202, 11533254, 14709383, 15220620, 16962392, 17389142, 17390010, 22389361, 24848090, 24848951, 24850948, 24850949, 24850952, 24854386, 24867221, 24867222, 25622888, 26736246, 26752849, 29225577, 32017005, 47365493, 48413311, 48416888, 48421347, 48421869, 48422978, 48424894, 48424895, 48425781, 48426108, 49718108, 49855899, 50105488, 50436459, 53786774, 56310669, 56311407, 56311428, 56311468, 56312131, 56312424
Target and Pathway
Target(s) mRNA of androgen receptor Target Info Antagonist [532398]
Estrogen receptor beta Target Info Agonist [532398]
KEGG Pathway Oocyte meiosis
Pathways in cancer
Prostate cancerhsa04915:Estrogen signaling pathway
Prolactin signaling pathway
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY networker_nongenomic_pathway:Plasma membrane estrogen receptor signaling
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha network
Reactome Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3R-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathwayWP706:SIDS Susceptibility Pathways
Ovarian Infertility Genes
References
Ref 526643Antiandrogenic effects of bisphenol A and nonylphenol on the function of androgen receptor. Toxicol Sci. 2003 Sep;75(1):40-6. Epub 2003 Jun 12.
Ref 532398Structure-activity relationships of bisphenol A analogs at estrogen receptors (ERs): discovery of an ERalpha-selective antagonist. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4031-6.

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