Drug General Information
Drug ID	D02RWK
Former ID	DNC005549
Drug Name	K-252a analogue
Indication	Discovery agent		Investigative	[527569]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Vascular endothelial growth factor receptor 2	Target Info	Inhibitor	[527569]
	Neurotrophic tyrosine kinase receptor 1	Target Info	Inhibitor	[527569]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Cytokine-cytokine receptor interaction
	Endocytosis
	PI3K-Akt signaling pathway
	VEGF signaling pathway
	Focal adhesion
	Proteoglycans in cancerhsa04010:MAPK signaling pathway
	Apoptosis
	Neurotrophin signaling pathway
	Inflammatory mediator regulation of TRP channels
	Pathways in cancer
	Transcriptional misregulation in cancer
	Thyroid cancer
	Central carbon metabolism in cancer
NetPath Pathway	IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway	Angiogenesis
	VEGF signaling pathway
Pathway Interaction Database	HIF-2-alpha transcription factor network
	Beta3 integrin cell surface interactions
	Signaling events mediated by TCPTP
	SHP2 signaling
	S1P1 pathway
	VEGF and VEGFR signaling network
	Integrins in angiogenesis
	Signaling events mediated by VEGFR1 and VEGFR2
	Notch-mediated HES/HEY networktrkrpathway:Neurotrophic factor-mediated Trk receptor signaling
Reactome	Neurophilin interactions with VEGF and VEGFR
	VEGF binds to VEGFR leading to receptor dimerization
	Integrin cell surface interactions
	EPHA-mediated growth cone collapse
	VEGFA-VEGFR2 Pathway
	VEGFR2 mediated cell proliferationR-HSA-170968:Frs2-mediated activation
	ARMS-mediated activation
	NGF-independant TRKA activation
	PI3K/AKT activation
WikiPathways	Focal Adhesion
	Nifedipine Activity
	Cardiac Progenitor Differentiation
	Signaling by VEGF
	AngiogenesisWP382:MAPK Signaling Pathway
	BDNF signaling pathway
	Integrated Pancreatic Cancer Pathway
	NGF signalling via TRKA from the plasma membrane
References
Ref 527569	J Med Chem. 2005 Jun 2;48(11):3776-83.Synthesis, modeling, and in vitro activity of (3'S)-epi-K-252a analogues. Elucidating the stereochemical requirements of the 3'-sugar alcohol on trkA tyrosine kinase activity.
Ref 527569	J Med Chem. 2005 Jun 2;48(11):3776-83.Synthesis, modeling, and in vitro activity of (3'S)-epi-K-252a analogues. Elucidating the stereochemical requirements of the 3'-sugar alcohol on trkA tyrosine kinase activity.

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